They will draw on the experience of the 50 ‘vanguard’ sites, which have led the development of new care models across the country. [CDATA[// > For staff, improved collaboration can help to make it easier to work with colleagues from other organisations. This long read sets out five priorities to help guide the approach to renewal across health and care. [CDATA[> Integrated Care Systems (ICSs) are the latest in a series of initiatives to develop integrated care in England. The main focus of the work at ‘place’ is to implement new care models. Some systems are therefore pursuing alternative arrangements, such as Greater Manchester where the 10 constituent CCGs are developing closer working arrangements with their co-terminous local authorities at the ‘place’ level (including through joint leadership) while the wider Greater Manchester health and care partnership supports some commissioning activities to be led across the system. Integrated care systems are made up of three major pillars of work: primary care networks, personalised care and population health management. Increasingly, providers are taking on commissioning-type roles (such as redesigning care pathways and ensuring medicines are used safely and effectively) and some local planning is done collaboratively across the commissioner–provider divide. At this level, providers may work together to join up their services through alliances or more formal contractual arrangements. Evidence from previous attempts to integrate care indicates that these changes will take time to deliver results. In an integrated care system, NHS organisations, in partnership with local councils and others, take collective responsibility for managing resources, delivering NHS standards, and improving the health of the population they serve. Key functions include setting and leading overall strategy, managing collective resources and performance, identifying and sharing best practice to reduce unwarranted variations in care, and leading changes that benefit from working at a larger scale such as digital, estates and workforce transformation. Health systems all around the world are having to adapt in response to this changing pattern of need. Following several decades during which the emphasis was on organisational autonomy and the separation of commissioners and providers, ICSs depend instead on collaboration and a focus on places and local populations as the driving forces for improvement. As a result, the NHS needs to work differently by providing more care in people’s homes and the community, and breaking down barriers between services. This experience enables our staff to understand and empathize with the needs of our patients, their families, and caregivers. ICSs are partnerships that bring together providers and commissioners of NHS services across a geographical area with local authorities and other local partners, to collectively plan and integrate care to meet the needs of their population. lessons are learned from this experience. In England, an integrated care system ( ICS) brings together the organisations planning, buying and providing publicly-funded healthcare – including mental health and community care services – to the population of a geographical area.